The proceed of a "fiscal cliff," a death of a horde of taxation and spending provisions, has extended implications for probably each American as chronicled in last week's front-page story in a Chattanooga Times Free Press.
In particular, investors should be wakeful of a integrate of poignant taxation supplies due to take outcome (or some-more rightly to expire) on New Year's Day, and should cruise holding movement now to lessen a intensity impact to their portfolios.
As of Jan. 1, many of a taxation cuts enacted in 2001 and 2003 are scheduled to sunset, permitting taxation rates to return to their prior levels. Although there are countless facets to a mercantile cliff, investors are quite influenced by a reversal of a rates on division income and long-term collateral gains. Going up, in box we were wondering.
The story of taxation on division income is tortuous, though a reasonable concede was determined in 2003 when a taxation rate on competent dividends was reduced to 15 percent.
Prior to a 2003 cut, dividends were treated as typical income and taxed during a tip extrinsic rate to that a taxpayer was subject. This rate was quite toilsome given dividends are distributions of corporate gain thatalready have been taxed during a association turn and that are not deductible as corporate expenses.
The scheduled changes meant that taxes on division income for a integrate filing jointly with an practiced sum income of $70,000 will burst from 15 percent to during slightest 25 percent and maybe 28 percent. Filers in a top income joint are slated to compensate 43.4 percent, including a new 3.8 percent surcharge to assistance account doing of a Affordable Care Act.
In expectation of a additional belt to shareholders, some open and many private companies are considering a acceleration of Jan division payouts into Dec to kick a taxation clock, during slightest for this quarter's distribution.
While it is doubtful that Congress will concede such a pointy boost to occur, high-dividend bonds would expected knowledge some offered vigour if a concede fails to emerge.
Perhaps some-more significantly, collateral gains taxes also are scheduled to boost in January, with rates augmenting from 15 percent to 20 percent for many taxpayers holding a batch for during slightest one year. However, a best wish of a grand discount on debt rebate centers around a offer to revoke typical income taxation rates though also to boost collateral gains to 25 percent. Any devise with a reasonable possibility of adoption would roughly positively embody some movement on this theme.
Given this scenario, a reassessment of required knowledge is appropriate.
In particular, investors who have amassed vast strong positions and are traditionally antithetic to realizing taxation gains should reconsider, given a odds that a taxation check subsequent year will be worse, and presumably most worse.
No one ever went pennyless by holding profits, as a observant goes. And remember that holding no movement is also a decision, one that competence outcome in a incomparable grant subsequent year to Uncle Sam.
Christopher A. Hopkins, CFA, is a clamp boss during BarnettCo.
Metgasco announced the successful raising of $10.4 million from the recent Share Purchase Plan. The proceeds of the Share Purchase Plan will be combined with the recent $10.2 million placement and existing cash reserves of $10 million to progress Metgasco?s 2012/13 work program.
?The successful capital raising is a sign of confidence from both our own shareholders and the broader financial community in the need for CSG production in NSW and eastern Australia, and the future of Metgasco?, Mr Henderson said.
Mr Henderson also said ?Through the renewal of our exploration licences, the approval of our first production licence and the strong support from Ministers Hartcher and Hazzard, it is clear that the CSG industry is recognised as being safe and that it has the support of the NSW Government.?
Metgasco is now moving ahead, with a focus of taking the company from its exploration phase to a production / commercial phase, with 2012/2013 field activities that include:
drilling of three lateral CSG wells to provide further confidence in well productivity and provide additional gas for local supplies;
drilling of the three core wells; and
acquisition of seismic and the drilling of the Rosella-1 well to test Metgasco?s conventional gas potential.
?In parallel with these field activities, Metgasco will be pursuing the studies, agreements and approvals to allow sales to the local, Northern Rivers market, as well as those required to provide gas to the eastern Australian and international markets,? Mr Henderson said.
(Reuters) - A failed backup power generator has forced Knight Capital Group to tell clients to route all stock orders away from the brokerage on Wednesday, as the effects of Sandy, the massive storm that slammed into the U.S. East Coast, were still being felt.
It was the second time in three months the Jersey City, New Jersey-based broker has had to ask clients to route orders elsewhere.
Knight, a top U.S. market maker - a brokerage that buys and sells stocks for clients and ensures orderly trading - said the generator failed before midday, affecting its institutional equities sales and trading, and market-making businesses.
Like many other firms in the New York metro area, the company was operating on backup energy after the massive storm Sandy hit late on Monday, knocking out power for millions.
Knight's clients have been told to send their NYSE-listed and Nasdaq stocks, along with options trades, elsewhere
"All computer interfaces with Knight will be shutdown with no new orders, both by phone or electronic, being accepted at this time," the company said.
A spokeswoman for Knight said the move was to "protect clients while we determine what the issue is."
MARKETS TRADING AS USUAL
All U.S. stock markets had been shut down on Monday and Tuesday in response to pressure from firms worried about employee safety during the storm, as well as concerns about markets functioning effectively on contingency plans with light staffing in place. It was the first time in 27 years that exchanges closed because of bad weather.
On Wednesday, stock markets opened as usual.
Three months earlier, Knight was forced to route orders to other brokerages due to a software glitch that sent a deluge of unintentional trades into the market, leaving it with a massive position it had to unload at a loss of over $400 million. Knight had to take on new investors to avoid bankruptcy.
The issue on Wednesday was unrelated.
"Many people are operating from some contingency place, and often that works fine, but sometimes there are hiccups," said Larry Leibowitz, NYSE Euronext's chief operating officer. "But as a whole, it's actually going quite well. We haven't heard of widespread problems."
The New York Stock Exchange is also operating on backup generators. Leibowitz said it has multiple backups in place, and that while it was told it might have power by Friday, NYSE was ready to run on generators through the weekend and beyond.
NYSE is in communication with Knight, he said, adding that Knight has a backup to its Jersey City backup, in Purchase, New York, but switching intraday could be risky for clients.
"They are being abundantly cautious to their customers and saying, 'you should route out so that if we have to do a switch or do something, you're not impacted,' and I commend them for that."
NOT A PANIC
Volume in U.S. stocks after the two-day closure was average.
"Its not a panic," Paul Weisbruch, vice president of exchange-traded fund and options sales and trading at Street One Financial, said of the Knight issue. "Because not that many people are trading." He said the company was getting calls from clients looking to reroute orders.
Fidelity, one of the biggest U.S. brokerages, said it uses multiple market makers, such as Citadel Securities, UBS AG, Goldman Sachs, and Citigroup, so rerouting orders was not a problem.
Noah Hamman, chief executive of AdvisorShares, a Bethesda, Maryland-based exchange-traded fund provider that uses Knight as its lead market maker, was a bit troubled when he heard Knight was rerouting orders.
"It is a little disconcerting for things like backup generators to not be working because these are relatively basic disaster recovery things to have in place," he said. "I will be curious to get some feedback to find out what happened."
As a result of the Knight issue, AdvisorShares saw a few of its ETFs, such as its Global Echo ETF and its Accuvest Global Long Short ETF and start trading at wider spreads than usual for a few hours, Hamman said.
Even with the issue, Hamman said he wasn't too worried about Knight. "It's one of those days you are expecting some things not to go right," he said.
Knight's shares were down 3.4 percent at $2.53 on Wednesday afternoon.
(Reporting by John McCrank; Editing by James Dalgleish, Bernard Orr and Marguerita Choy)
Early Monday morning, two US Coast Guard helicopters rescued 14 crew members of the HMS Bounty, ensnared by hurricane Sandy. But the Coast Guard is still searching for two missing crew.
By Peter Grier,?Staff writer / October 29, 2012
In this file photo, the tall ship HMS Bounty sails on Lake Erie off Cleveland. The U.S. Coast Guard has rescued 14 members of the crew forced to abandon the HMS Bounty caught in Hurricane Sandy off North Carolina. The Coast Guard is searching for two other crew members.
Mark Duncan/AP/File
Enlarge
Hurricane Sandy has already claimed a well-known victim, as the massive storm has sunk the tall ship HMS Bounty off the coast of North Carolina.
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Two US Coast Guard helicopters rescued 14 of the ship?s 16 crew members early Monday morning. The Coast Guard is still searching for the two missing crew, a service spokesman said.
The ship issued a distress call at 6:30, Eastern time, on Sunday evening, according to the website of the HMS Bounty Organization. At that time it lost power, and pumps were thus unable to keep up with water rising in the ship. The vessel was taking on two feet of water per hour, according to the Associated Press.
Bounty Organization officials contacted the Coast Guard, which sent a C-130 aircraft to track the distressed vessel at its location, approximately 90 miles southeast of Cape Hatteras, N.C. By 4:30 a.m., the situation was so bad that the captain ordered the ship abandoned, according to the website. The Coast Guard says its helicopters pulled 14 survivors from lifeboats by 6:30 a.m. Monday.
In 1789, the original HMS Bounty played a role in the one of the most famous stories in maritime history. A small three-masted sailing vessel sent by Britain?s Royal Navy to the Pacific on a supply expedition, the Bounty was roiled by tension between its crew and Capt. William Bligh.
After landing in Tahiti and taking on a cargo of breadfruit, the Bounty set sail for the West Indies. It never reached that destination. Instead, mate Fletcher Christian led the men in a mutiny against what history has long portrayed as the abuses of Bligh. Bligh and his loyalists were allowed to sail off in a longboat. They reached safety at the Dutch-owned port of Kupang after an arduous journey.
Christian and his followers ended up on Pitcairn Island. They burned the Bounty there and settled on the island with the ship?s livestock, other provisions, and some Tahitian natives.
Passing ships did not discover the enclave until after the turn of the century. At that time only one of the mutineers, and a number of Tahitian women, remained alive.
The ship that sank Monday was a replica of the original Bounty, built for the 1962 ?Mutiny on the Bounty? movie, which starred Marlon Brando as Christian. It was constructed from original Royal Navy plans, but was made one-third larger to accommodate cameras and other filming equipment.
Over the years it has starred in a number of sailing movies, including the ?Pirates of the Caribbean? film series, in which it was the pirate ship Black Pearl.
Tracie Simonin, director of the HMS Bounty Organization, said that the ship left Connecticut last week bound for Florida and was in contact with the National Hurricane Center as it tried to skirt the massive storm barreling up the East Coast.
Learn how to improvise your own Halloween horror music. Before laptops and Logic, TV and and Technicolor, early horror film composers at the dawn of the 20th century used improvisation to enhance the silent silver screens. They composed hauntingly dramatic scores, freaky monster music, and thrilling moments of Halloween horror by combining improvisation and traditional classical music scores.
Unlike horror film composers today that write directly for film digitally, early film composers like J.S. Zamecnik combined traditional classical music and original dramatic motifs into ?playbooks? for the hundreds of pianists, theater orchestras, and organists who performed live at the picture palace.
Photoplay books like Sam Fox Moving Picture Music Vols. 1-3 provided musical direction and cues for improvisation. Other books simply pulled out sections from specific classical works and gave a list of excerpts and music cues to fit a specific film. The early silent film composers of these books used tried and true musical ideas to create spooky, scary, and dramatic music cues.
Contemporary film composers sync up audio to video using their iPad or laptops. While high-end film gigs use a live orchestra, conductor, and recording sessions, many indie composers simply use improvisation to find inspiration for their latest Halloween horror flick at home. A good improv can yield hours of good spooky material!
While most of the music you improvise won?t see the light of day, learning how to improvise these musical sketches in a variety of styles will improve both your compositional and ear training skills.
We?re going to use a particular short film clip as an example of how to improvise and then develop your score for a horror movie.
Halloween ear training improv practice
Start by watching the Halloween silent video excerpt below. In this excerpt, our hero Jettison sleeps peacefully as an evil alien being prepares to abduct him into a horrific alternate dimension:
Watch the video a few times. Log important moments of tension, action, and drama.
Example timecode list for key moments in the video
If you have a program like Logic, Garageband, or Protools, import the video into your program and improvise with your MIDI controller.
If you don?t have a good program for film scoring, just grab your instrument and watch the video in your media player or online. Record your performances in Quicktime or Audacity by manually syncing the video:
Hit Record
Tap four beats to your metronome
On beat four start the video by clicking PLAY
Record your improvisation
Choose one or maybe a few simple instruments. The goal is not to make a finished track, but to develop a few ideas to use later.
Don?t worry about quantizing, mixing, or reverb!
Use harmonic tension to increase suspense, brass and percussion to build drama, and synth effects to match the images.
Add accents for scene changes and important moments.
Play with a variety of styles: fun, scary, quirky, dramatic, sci-fi, etc.
Here?s an example of the rough musical ?sketch? this might produce:
Clearly there are a lot of issues with this track so far!
Use your listening skills and hear where the track needs improvement. Quantize, automate channels, and add a fade-out. Improve video sync by moving dramatic accents. Change the tempo.
In the second version of this improvised score, I added an accelerando to the final measure:
In the final version of this music sketch, I added in a few sound effects and audio effects to give the track a more sci-fi feel. To minimize the horns at the end, I dropped a noisy rocket effect and blended it with the final accents to transition to the next scene where the alien abducts our hero:
Here?s the finished version with the audio set to video:
What d?you think? Can you hear and see how the score has been developed to better suit the video content?
Try it yourself! Here are a few exercises you could do with this clip, or any other horror movie excerpt:
Halloween Activity 1
Create a spooky soundtrack in the style of the old silent era films. Use piano, organs, and acoustic instruments. Keep rhythms and harmony simple.
Halloween Activity 2
Use only synthesized sounds and electronic instruments to create a scary sci-fi Halloween soundtrack. Think Forbidden Planet or Blade Runner.
Halloween Activity 3
Get dramatic! Create an orchestral Halloween sound in your home studio. Start with piano and then orchestrate the piano part for full orchestra. Add brass, strings, percussion, and woodwinds. Avoid using too much ?tutti? (all instruments playing at the same time). Mix and match the musical palette to create spooky ensemble sounds.
Recommended resources
Download excerpts from all three volumes of J.S. Zamecnik?s Moving Pictures at the Petrucci Library. The Petrucci Library provides musicians with both old and new scores, from opera to string quartets to tape music. Use the simple search engine to find scores by composer, era, and instrumentation.
Find out more about photoplay music in the Silent Era at the Mont Alto?s Motion Picture Orchestra website.
Share your spooky Halloween music with us! Post a link to your album or improv in the comments below.
We?ll continue tomorrow with some great examples of effective film music and the techniques used. Until then, if you have any questions, just give a shout!
Goodnight Seattle! Man, we sure had a blast at last night's reader meetup. The party went down at the Showbox Theater, right across the street from the city's fishy Pike Place Market. Droves of Emerald City Engadget readers braved the drizzle to hang out, talk tech and win some of the year's coolest gadgets -- including a brand new Microsoft Surface RT (yes, it came with a keyboard), a Nexus 7 and a pair of Kindle Fire HDs. We learned a lot of valuable lessons: everything's better with a green screen, people want to know where we go sweater shopping and Seattle's gadget geeks don't really know all that much about the Wu Tang Clan. Thanks everyone for coming out -- we'll see you in New York City!
Algerian Foreign Minister Mourad Medelci, centre, greets US Secretary of State Hillary Rodham Clinton, upon her arrival at Houari Boumediene Airport, in Algiers, Algeria, Monday, Oct. 29, 2012. US Secretary Secretary of State Hillary Rodham Clinton is on a five-day trip overseas to increase pressure on Mali's al-Qaida-linked rebels and help Balkan nations end long-simmering ethnic and political disagreements. (AP Photo, Saul Loeb, Pool)
Algerian Foreign Minister Mourad Medelci, centre, greets US Secretary of State Hillary Rodham Clinton, upon her arrival at Houari Boumediene Airport, in Algiers, Algeria, Monday, Oct. 29, 2012. US Secretary Secretary of State Hillary Rodham Clinton is on a five-day trip overseas to increase pressure on Mali's al-Qaida-linked rebels and help Balkan nations end long-simmering ethnic and political disagreements. (AP Photo, Saul Loeb, Pool)
ALGEIRS, Algeria (AP) ? U.S. Secretary of State Hillary Rodham Clinton sought Algeria's assistance on Monday for any future military intervention in Mali, pressing the North African nation to provide intelligence ? if not boots on the ground ? to help rout the al-Qaida-linked militants across its southern border.
Clinton, on the first stop of a five-day trip overseas, met with Algerian President Abdelaziz Bouteflika as the United States and its allies ramped up preparations to fight northern Mali's breakaway Islamist republic.
When Mali's democratically elected leader was ousted in a military coup in March, Tuareg rebels seized on the power vacuum and within weeks took control of the north, aided by an Islamist faction. The Islamists then quickly ousted the Tuaregs and took control of half the country.
The U.N. Security Council has unanimously approved the idea of an African-led military force to help the Malian army oust Islamic militants, but its details are still unclear.
One plan would see Mali's embattled government in the south and its West African neighbors taking the military lead to battle with the militants, with the United States and European countries in support.
Any military intervention would likely require Algeria, whose reforms have headed off the Arab Spring tumult experienced by neighbors such as Libya and Tunisia and left it with the strongest military and best intelligence in the region.
Clinton said she and Bouteflika spoke at length about Mali, with the Algerian leader appearing to caution against any rash action.
"I very much appreciated the president's analysis based on his long experience as to the many complicated factors that have to be addressed to deal with the internal insecurity in Mali and the terrorist and drug trafficking threat that is posed to the region and beyond," Clinton told reporters.
She said they agreed to continue discussions with the U.N. and African nations "to determine the most effective approaches that we should be taking."
Washington is keen to eliminate northern Mali as a haven for al-Qaida in the Islamic Maghreb, which may have been involved in September's attack on the U.S. Consulate in the Libyan city of Benghazi. Mali even came up in the U.S. election campaign, with Republican challenger Mitt Romney citing the African nation's instability in a foreign policy debate with President Barack Obama.
As further evidence of the U.S. intensifying its diplomatic work in Mali, Maria Otero, an undersecretary of state for civilian security, democracy and human rights, was to travel to Mali on Monday. She is the highest-ranking Obama administration official to visit since the coup. She'll meet with Mali's prime minister, human rights activists and internal refugees.
The 15-nation West African regional bloc, the Economic Community of West African States, or ECOWAS, has discussed sending 3,000 troops to help oust the Islamist militants from the north. Many, though, question how Mali's weak military could take the lead on such an intervention and analysts believe more ECOWAS soldiers would be needed to take and hold the France-sized desert area now controlled by the militants.
While the U.S. wants to see the rebels routed, it has no interest in active involvement in the military mission, unless Mali and West African states explicitly ask for such assistance, a senior American diplomat in Africa said. The official demanded anonymity because he wasn't authorized to speak publicly on the matter.
From Algeria, Clinton left for three days of talks in the Balkans, arriving Monday night in the Bosnian capital of Sarajevo.
She plans to join the European Union's top diplomat in meetings with the leaders of Bosnia, Serbia and Kosovo, urging those nations to make the necessary reforms to join the EU and NATO. She'll finish with meetings in Croatia and Albania, NATO's two newest members.
Don your best cowboy hat, put on some plaid, and take in all the fun and excitement of three events that celebrate the best in Edmonton?s agriculture and western heritage! From November 2 ? 11, three events offer up a plethora of activities ? many of which are free! ? featuring everything from family entertainment to superstar country musicians to beer-fueled nightlife. Here are some of the highlights:
River City Round Up (Nov 2 -11):?This city-wide festival is the celebration of all things country! The kick-off festivities will set the the bar high for ten days of fun, with a FREE performance by Canadian Country Music Legend George Canyon on November 3 at 5:30 pm, followed by a spectacular fireworks display. Throughout the week, various activities include a chili cook-off, pancake breakfasts, family crafts and games, beer gardens, live music and entertainment, cultural performances, and food trucks. For a detailed list of events, including dates and times, visit www.rivercityroundup.com. Most events take place at Churchill Square.
Canadian Finals Rodeo (Nov 7 -11):?Take in the thrilling action of rodeo events like barrel racing, bull riding, and steer wrestling. On November 7 enjoy a live performance by country superstar Dean Brody, and on November 8 watch the very talented and popular Chris Young perform. Nightly shows begin at 7 pm, with 1 pm matinee performances on Saturday and Sunday (Nov 10 ? 11). Tickets $25 ? $70 in advance; visit?www.cfr.ca/tickets for more ticket information, or www.ticketmaster.ca to purchase tickets.
FarmFair International (Nov 4 ? 11): This agricultural show features an extensive line-up of events, including activities and entertainment in Kid?s Country for children, cold drinks and a relaxed, 18+ atmosphere in The Saloon lounge, delicious barbecue food at The Buckle, and shopping for western wear and tack in The RAM Country Marketplace. For a full list of activities, dates, and times, visit www.farmfair.ca.
Home > Business Bay, Commercial Properties for Rent, Dubai > Fantastic Full Floor Fitted Office Space | Business Bay, Dubai | Commercial Properties for Rent
Fantastic full floor fitted office space in Churchill Tower located in the heart of Business Bay is available for lease. Only DED licensed companies can operate from this space. This is a fine finish tower with quality fit outs in place. The tower has easy access from Al Khail Road . It is located on a high floor and offers spectacular panoramic views of the Lake, Business Bay area, Sheikh Zayed Road, Racecourse & the prestigious Burj Khalifa. The tower has a full commercial floor available measuring an area of 13160 square feet. The full floor is provided with 15 reserved car parking space. To know more about this unit, please feel free to contact Provident Estate. The residences and commercial enterprises at Business Bay feature industrial working spaces, comfortable and luxurious residential units and contemporary facilities and amenities. Playing areas, arcades and landscaped plazas provided by the Courtyard. The Courtyard is a combination of modern architectural themes with exclusive amenities, while the Podium is a unique feature that links the residential towers and provides covered walkways, fountains and pedestrian friendly lane. Churchill is just a hop away from the prestigious Sheikh Zayed Road, close to Burj Khalifa, the worlds tallest building and a few minutes away from the magnificent Emirates Towers, business people will finally be able to flaunt the most enviable address for both business and living. Contact: +971 56 657 7326.
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It?s a BOY for Giuliana and Bill Rancic!! Since these two wanted to keep the gender of their baby a secret for this gorgeous baby shower, there were so many pink and blue elements that definitely kept their guests guessing. Mindy Weiss did a fabulous job designing and coordinating the event? how amazing does that pool look?! Between the flowy, white tents and massive balloons, we can?t decide which part is our favorite!
Giuliana and Bill shared the surprise after cutting into their tiered cake by Cupcakes Couture of Manhattan Beach, revealing a blue interior!! We can?t help but smile when we see them opening the huge box full of blue balloons? seriously, this is just the cutest idea ever! Guests enjoyed OneHope Wine, visited different activity stations and soaked up some sun? it was the perfect day for a baby shower!
We had so much fun helping with this shower, which was also featured in Life & Style Magazine!! These photos by Elizabeth Messina just blows us away!
Be Prepared to Be Inspired?
The excited and happy couple!!
Super cute signs with words like ?giggle,? ?wiggle,? ?crawl,? and ?lullaby? were place all over!!
ONEHOPE donates half of its profits to designated charities? proceeds from their Chardonnay go toward the Fight Against Breast Cancer.
We have a soft spot for flowy tents!
Giuliana checked out a few scents from the custom perfume bar by Kamilyin!
Adorable onesies doubled as decor! So sweet!
This box filled with balloons had guests on their toes!
This red and black bar is amazing!! We love the huge G & B letters!
How cute is this bookmark station?! Just to make sure that Dad gets some loving, too :)
There was a little Sweet Lucies ice cream station! We are obsessed with this organic goodness :)
Cake push pops, monogrammed cookies and yummy macarons by Cupcakes Couture of Manhattan Beach!!
A picture we snapped with the expecting couple after the shower!!
Playing video games is definitely a fun pastime, but sometimes, it can become a source of irritation that has virtually nothing to do with the game, because it is represented by the computer system that we are using our PC.
Using a laptop or desktop computer to play the latest games with high-end, you might happen to turn your gaming experience into an experience more and more annoying every passing moment, and this is because you meet a lot of lag, the game crashes, and almost always fails in the most important moments ?
The reason is very simple, is because the traditional desktop or laptop computers have graphics cards and other components of the same quality as those that are used in computers built for video games.For this reason, to experience the best gaming experience, you should seriously think about buying one of the many specialized computers for the game available on the market today.
If you try to do a search within your computer, even if you are not experienced, you will recognize precisely what kind of components are present. The PCs designed for gaming are characterized by two basic components:
a high-end motherboard, which is crucial to make it possible for each member to talk at very large
an graphics card with a chip of very high memory, together with a processor of excellent quality and high speed
Each of these elements is essential to make sure that your game can run without effort and without any delay when playing on-line or off-line.
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A good computer video game will also have an excellent cooling system of its components, this is essential to maintain a good temperature when the cards are performing high-speed operations, thus avoiding any risk of overheating.
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You?ll find that the cards we mentioned play a vital role especially when you find yourself playing a shooter in first person. The real reason for this is simply because the first-person shooter games are heavily dependent on speed, and this is the only way in which players can survive.
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There are two options for obtaining a good gaming computer:
the first method is to purchase online by choosing a store that specializes in this type of computer
you could build one with your hands
In fact, now you also have the option to contact a specialized company that will build your gaming computer for you with the only difference that you can tell them exactly what cards you want to use. Sometimes this options can work very well, because each type of card can produce exceptional results in terms of performance.?The second option offers more flexibility in determining which components to use, allowing you to also choose based on price, so if you want to save or spend much more, as well as give you a reward for the pleasure of having built your PC with your hands.
Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identifiedPublic release date: 29-Oct-2012 [ | E-mail | Share ]
Contact: Jeremy Moore jeremy.moore@aacr.org 215-446-7109 American Association for Cancer Research
PHILADELPHIA New insight into the aggressive behavior of certain adult B-acute lymphoblastic leukemias has provided researchers with a potential new prognostic biomarker and a promising new therapeutic target.
The research, conducted by Ari Melnick, M.D., associate professor of medicine and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell Medical College and a hematologist-oncologist at New York-Presbyterian Hospital/Weill Cornell Medical Center, and colleagues, was published in Cancer Discovery, a journal of the American Association for Cancer Research.
Although B-acute lymphoblastic leukemia is highly curable in children, the disease is usually fatal in adults, and researchers have yet to identify why this is the case. Part of the explanation for the poorer outcomes in adults is the higher frequency of genetic alterations associated with unfavorable prognosis.
In order to better understand why these genetic alterations are associated with poor outcomes, Melnick and colleagues studied 215 diagnostic specimens obtained from adults with B-acute lymphoblastic leukemia who were participating in a large Eastern Cooperative Oncology Group phase III clinical trial.
"We performed an integrative epigenomics study to decode the instructions that determine how these cells behave," Melnick said. "The hope was that this would allow us to identify better survival biomarkers and new therapeutic targets."
In many cancers, genetic alterations work in conjunction with epigenetic changes (changes in the way that DNA is modified and packaged) to promote cancerous behaviors. Looking at the B-acute lymphoblastic leukemia specimens, Melnick and colleagues found that many of the leukemias' bad traits were a result of changes in the epigenetic code. In many cases, the epigenetic changes were directly linked to the proteins generated from the genetic alterations and could be used to identify key master regulators required for the leukemic cells to live, according to Melnick.
"For example, we found that a cell surface molecule called CD25 was an extremely powerful indicator of the presence of the most aggressive and fatal cases," Melnick said.
The researchers also discovered that abnormal forms of the E2A and MLL proteins occurring in B-acute lymphoblastic leukemias directly reprogram epigenetic settings at their binding sites throughout the genome.
Most notably, the researchers found that mutant forms of MLL epigenetically reprogramed leukemia cells to express the powerful oncoprotein BCL6, and that BCL6 was required to maintain the proliferation and survival of the leukemia cells.
"We then designed inhibitors of BCL6 and showed that we could kill leukemia cells from patients enrolled in the clinical trial by blocking its function," Melnick said.
Based on these results, the researchers plan to use CD25 as a biomarker to identify those patients who have the worst disease in the next set of clinical trials, and to tailor treatment appropriately. In addition, BCL6 inhibitors are currently being translated for use in humans, and they hope to develop clinical trials targeting BCL6 in MLL-rearranged leukemias.
"These results will ultimately lead to biomarkers that help guide treatment and to the development of therapies that will be more effective for patients with this aggressive form of leukemia," Melnick said.
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About the American Association for Cancer Research
Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.
For more information about the AACR, visit www.AACR.org.
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Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identifiedPublic release date: 29-Oct-2012 [ | E-mail | Share ]
Contact: Jeremy Moore jeremy.moore@aacr.org 215-446-7109 American Association for Cancer Research
PHILADELPHIA New insight into the aggressive behavior of certain adult B-acute lymphoblastic leukemias has provided researchers with a potential new prognostic biomarker and a promising new therapeutic target.
The research, conducted by Ari Melnick, M.D., associate professor of medicine and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell Medical College and a hematologist-oncologist at New York-Presbyterian Hospital/Weill Cornell Medical Center, and colleagues, was published in Cancer Discovery, a journal of the American Association for Cancer Research.
Although B-acute lymphoblastic leukemia is highly curable in children, the disease is usually fatal in adults, and researchers have yet to identify why this is the case. Part of the explanation for the poorer outcomes in adults is the higher frequency of genetic alterations associated with unfavorable prognosis.
In order to better understand why these genetic alterations are associated with poor outcomes, Melnick and colleagues studied 215 diagnostic specimens obtained from adults with B-acute lymphoblastic leukemia who were participating in a large Eastern Cooperative Oncology Group phase III clinical trial.
"We performed an integrative epigenomics study to decode the instructions that determine how these cells behave," Melnick said. "The hope was that this would allow us to identify better survival biomarkers and new therapeutic targets."
In many cancers, genetic alterations work in conjunction with epigenetic changes (changes in the way that DNA is modified and packaged) to promote cancerous behaviors. Looking at the B-acute lymphoblastic leukemia specimens, Melnick and colleagues found that many of the leukemias' bad traits were a result of changes in the epigenetic code. In many cases, the epigenetic changes were directly linked to the proteins generated from the genetic alterations and could be used to identify key master regulators required for the leukemic cells to live, according to Melnick.
"For example, we found that a cell surface molecule called CD25 was an extremely powerful indicator of the presence of the most aggressive and fatal cases," Melnick said.
The researchers also discovered that abnormal forms of the E2A and MLL proteins occurring in B-acute lymphoblastic leukemias directly reprogram epigenetic settings at their binding sites throughout the genome.
Most notably, the researchers found that mutant forms of MLL epigenetically reprogramed leukemia cells to express the powerful oncoprotein BCL6, and that BCL6 was required to maintain the proliferation and survival of the leukemia cells.
"We then designed inhibitors of BCL6 and showed that we could kill leukemia cells from patients enrolled in the clinical trial by blocking its function," Melnick said.
Based on these results, the researchers plan to use CD25 as a biomarker to identify those patients who have the worst disease in the next set of clinical trials, and to tailor treatment appropriately. In addition, BCL6 inhibitors are currently being translated for use in humans, and they hope to develop clinical trials targeting BCL6 in MLL-rearranged leukemias.
"These results will ultimately lead to biomarkers that help guide treatment and to the development of therapies that will be more effective for patients with this aggressive form of leukemia," Melnick said.
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About the American Association for Cancer Research
Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.
For more information about the AACR, visit www.AACR.org.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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Public release date: 29-Oct-2012
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